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KMID : 0351619720130020387
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Kyungpook Medical Journal
1972 Volume.13 No. 2 p.387 ~ p.395
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Clinical application of 2,2´-Methylene bis (3,4,6-trichlorophenoxyacetic acid) "MTPA" on Clonorchiasis.
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Abstract
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The effect of MTPA was observed in 173 clono. chiasis patients who visited to the department of pharmacology, Kyungpook n~itional university, school of medicine, from Sep. , 1969 to Jun, , 1971 and 20, Mar. ,1972.
In 173 patients, 162 patients had normal liver function, 10 patients were complicated with acute hepatitis and one of the patients had been inserted T tube into his common bile duct since 7 months after operation for bile stone.
MTPA was administered oraly in daily dose of 715 mg/Kg, which was divided into three equal part and given after each meal. To each patient the drug was given for 4 or 5 cures and one cure was composed of 6 days of drug administration and the interval between each cure was 10 days.
The effect of drug was estimated with counting the number of eggs of clonorchis in the feces by the IVIGL method, the results were expressed as "negative", completly disappeared, ant "80b diminution", number of the eggs reduced more than 80~ than before treatment. Besides egg count, general symptoms and liver fun~:tion before ant after medication, and side effectsinduced by drug were also observed.
The results obtained as follows.
1) In 51 patients treated ~ith lOmg/Iig/day for 4 .or 5 cures, egg-negative rate was 49~ and 80jo diminution was 37%
2) In 31 patients treated with 7 mg/hg/day for first cure and than 15mgjI:;/day for 3 or 4 cures, egg-negative rate was 58.1% and SO; diminution was 35.5 ~.
3) In 80 patients given in dose of lOmg/Kg/ day for first cure and then 15mg/Kg/day for 3 cures or 15mg/Kg/day for 4 cures, the eggnegative rate were 64.7~~, and 69.5 o and 80~ diminution rate were 29.4?;, and 23.9 ~ respectively.
4) In the patients administered with MTPA, the gerneral symptoms and signs such as fatigue, anoraYia, indigestion etc. ant hepatomegaly .. were improved.
5) In 10 patients complicated with acute hepatitis and a~?ministered ;with 3mg/Kg/day for first cure ant continued by 7mg/Kg/day second cure and then 15mg/Kg/day for 3 cures, 7 of them were egg-negative, 2 of them were 80 o diminution.
6) Side effects induced by drug were gastric pain, abdominal pain, diarrhea, dizziness, head-ache, fatigue and fever. But the side effects were so mild that discontinuance of administration of drug was not necessary in most cases.
7) In the patient inserted with T tube while administered with 7mg/Kg/day of A´IT]? ~, clonorchis sinensis flew out from the T tube in living, but with 15mg/Kg/day, clonorchis sinensis flew out in dead.
From above results we think that l~ITPA is a useful drug for treatment of clonorchiais, and 15mg/Kg/day is enough to kill clonorchis sinensis in the body.
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